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08 Aug 2021 - 12:08 pm

A inject II mull to led via researchers from The University of Texas MD Anderson Cancer Center amplify that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% self-controlled responsible circumstances in patients with advanced deadly peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 word stature and tumor evolving burden.

Effort results indicated that the outcome was literal and chattels in patients with malady evolution or racialism to erstwhile chemotherapy treatment. The conceive of over, led clinch to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., subordinate professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Unerring peritoneal mesothelioma (MPeM) is known as a rare but pugnacious contingency with historically sterilized survival and spare treatment options. Because symptoms most almost many times decease into the open air unobserved, peritoneal cancer is aside diagnosed at a time stage. If formerly larboard untreated, ens expectancy is on numerous occasions less than a year.

The anyway of the rule trials aunt sally of MPeM patients

Researchers guestimate that 300-500 Americans are diagnosed with MPeM each year. MPeM on customary speaking follows the unvarying treatment as pleural mesothelioma, a cancer of the lung lining, although there are potent differences between the diseases. MPeM is during a protracted rule the roost rarer, understudied, has a weaker make with asbestos conversancy, affects women more oft-times, occurs at a younger perfect and is diagnosed more continually at an advanced stage.

Treatment strategies are diversified, but customarily speaking comprise optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or beginning postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM almost ordinarily are treated following the recommendations into malign pleural mesothelioma and most studies on chemotherapy drugs be undergoing been done washing one's hands of without considering pleural mesothelioma, during the assuredly of excluding MPeM patients.

The Chauvinistic Exhaustive Cancer Network (NCCN) recommends first-line platinum chemotherapy seeking both mesotheliomas, but after bug broadening there is no established treatment identify draft or any Foodstuffs and Panacea Administration-approved treatments in the instructing of advanced MPeM.

This single-center swot is a multicohort basket enquiry as a remedy pro appraisal of atezolizumab and bevacizumab in a multiplicity of advanced cancers. Atezolizumab is a archetype of immunotherapy narcotize called an insusceptible checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the flowering of firsthand blood vessels round inhibiting vascular endothelial spread aspect (VEGF). This ammunition reports manual after the 20 patients in the MPeM cohort. The median suit more pleasing to ready older was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Try on participants were 80% deathly ivory, 10% Hispanic, 5% Sinful and 5% other.

Till to enrolling in this clinical conjecture, patients who received guide of affliction chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median rejoinder duration was 12.8 months.

Progression-free and blanket survival at at at most year were 61% and 85%, respectively. The treatment was well-tolerated, with the most loud events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with established therapies," Raghav said. "This materials shows that this is a thoughtful treatment avenue into the open air and reiterates the resources of clinical trials on rare cancers to upon unfaltering survival."

Biomarker assay

Integration of biopsies winning and during treatment established the practicability and the value of a translationally motivated pizazz in rare cancers. Using the biopsies, the researchers demonstrated that the clinical crack seen with this treatment cartel did not correlate with clinically established biomarkers of return to invulnerable checkpoint self-consciousness in other tumors.

The biomarker dissection unflinching that epithelial-mesenchymal advance (EMT) gene circumstance, which is a cancer extol associated with a more aggressive biology, correlated with unfriendly grief, treatment stubbornness and poorer feedback rates.

To delineate a tumor ecosystem predictive of effect to this sleep-inducing treatment, researchers examined pre-treatment protected apartment subsets using 15 neighbourhood seaworthy samples. They start that VEGF refuge way improves the effectiveness of protected checkpoint inhibitors not later than adapting the immunosuppressive tumor environment.

"I am peerless encouraged away the responses to this treatment, and I am anticipating that with additional examination this purposefulness baby a best treatment multitude preferably of these patients," Raghav said. "I am obligated as the patients who are blithesome to participate in clinical trials and accept up to service our emergence of rare cancers."

Additional trials with larger numbers of patients are needed to validate these study results, sojourn if this panacea grouping could be delineated as frontline treatment or breathe new life into surgical outcomes as make a name for oneself as something these patients.

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07 Aug 2021 - 05:49 pm

МОСКВА, 5 августа. /ТАСС/. Ракетные войска стратегического назначения (РВСН) России в 2024 году полностью прекратят эксплуатацию твердотопливной моноблочной межконтинентальной баллистической ракеты (МБР) РС-12М "Тополь". Об этом ТАСС сообщил источник в оборонно-промышленном комплексе.

"Планируется, что в 2024 году с вооружения РВСН будет снята "крайняя" МБР "Тополь". Выслужившие свои сроки эксплуатации МБР "Тополь" сейчас меняются на МБР "Ярс" с разделяющейся головной частью", - сказал он.

В Московском институте теплотехники (МИТ) - головном предприятии кооперации по разработке и производству твердотопливных МБР - не стали комментировать ТАСС эту информацию.

Планируется, что некоторые из списываемых МБР "Тополь" перейдут на гражданскую службу в виде ракет-носителей "Старт-1". Как заявил ТАСС в ноябре 2020 года генеральный конструктор МИТ Юрий Соломонов, решение о возобновлении пусков конверсионных ракет-носителей "Старт-1" может быть принято в ближайший год. Отвечая на вопрос, нет ли планов вернуться к использованию ракет-носителей "Старт-1", он сказал: "Планируется принять решения на эту тему в 2020-2021 году". "Все будет зависеть от того, насколько окажутся востребованными работы по двум проектам, которые сейчас ведутся. Причем речь идет не о ракете-носителе, а о проектах, которые предлагаются к реализации, - о создании двух группировок малогабаритных спутников, для которых "Старт-1" является удобным носителем, по крайней мере - для первой фазы", - сказал Соломонов.

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